Mix mayonnaise, ketchup, mustard, and pickle relish in a bowl to make the special sauce.

Season ground beef with garlic powder, onion powder, paprika, Worcestershire sauce, salt, and pepper.

Heat a skillet and cook the seasoned ground beef over medium-high heat until browned.

While the beef cooks, chop lettuce, halve cherry tomatoes, slice avocado, and thinly slice the red onion.

Divide chopped lettuce into bowls as the base for the hamburger bowls.

Top each bowl with cooked ground beef, cherry tomatoes, avocado slices, shredded cheddar cheese, and red onion.

Drizzle special sauce over the bowls or serve it on the side for individual customization.

Add optional toppings like pickles, jalapeños, or sesame seeds, and serve immediately.